Systematic Review on the Effectiveness of Strategies for Increasing Insulin Bioavailability in Oral Route Delivery Systems Based on Manufacturing Techniques and Materials Used

Diabetes is a metabolic disease characterized by hyperglycemia due to impaired insulin secretion, action, or both. All patients with type 1 diabetes and many 2 require therapy achieve reasonable glycemic control. During this time, given through the subcutaneous injection route because it can be destroyed gastric acid when orally. Until now, studies have developed oral using various delivery system strategies. This systematic literature review aims answer several questions about effect of technique material on increasing bioavailability best that produce bioavailability. We searched for published articles regarding development insulin. Bioavailability parameters were assessed based plasma levels relative values and/or glucose pharmacological values. Conclusion: The manufacturing in affects stability maintaining its conformation provide therapeutic effect. substance properties paving way across barriers digestive tract. To date, results obtained 73.10% achieved mesoporous silica nanoparticles (MSN) layer-by-layer coated [poly (methacrylic acid-co-vinyl triethoxylsilane)] (PMV)].
 Keywords: bioavailability, diabetes, insulin, nanoparticles, system.